This 40 yr male had upper abdominal pain for 3 months. A video-endoscopic examination of esophagus, stomach and duodenum was performed. A large 2.5x2.5 cm chronic ulcer was detected in the first part (bulb) of duodenum. A gastric biopsy was taken for diagnosis of Helicobacter infection and a rapid urease test done which was positive. He received triple therapy (2 antibiotics and acid suppressive drug for one week) to eradicate Helicobacter pylori infection. Ulcer disease showed rapid clinical and endoscopic healing. Eradication of Helicobacter pylori infection led to permanent ulcer cure.