Symptoms of serotonin syndrome include a classic triad of mental status changes (eg, anxiety, delirium,
confusion, restlessness), autonomic dysregulation (eg, diaphoresis, tachycardia, hypertension,
hyperthermia, diarrhea, mydriasis), and neuromuscular hyperactivity (eg, hyperreflexia, tremor, rigidity,
myoclonus, ocular clonus). Serotonin syndrome is clinically diagnosed and laboratory tests are used to rule
out other etiologies. It usually occurs due to inadvertent interactions between drugs, therapeutic use of
multiple serotonergic agents, or serotonergic medication overdose. Treatment involves discontinuation of
serotonergic drugs, supportive measures, and sedation with benzodiazepines. In severe cases, a serotonin
antagonist (cyproheptadine) may be used.