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Cushing's disease is a serious condition of an excess of the steroid hormone cortisol in the blood level caused by a pituitary tumor secreting adrenocorticotropic hormone (ACTH). ACTH is a hormone produced by the normal pituitary gland. ACTH stimulates the adrenal glands (located on top of the kidneys) to produce cortisol, commonly referred to as the stress hormone.
Each person's knee is different. This is why UC San Diego Health offers several surgical options for knee replacements to tailor care to each person's injury and health. Each surgical approach has benefits for the right surgical candidate. Our surgeons can discuss what option is most appropriate for each person.
To learn more about knee replacement options at UC San Diego Health, visit:
https://health.ucsd.edu/specia....lties/orthopedics/jo
Francis Gonzales, MD, is a board-certified orthopedic surgeon who specializes in adult hip and knee joint replacement surgery. Learn more about Dr. Gonzales: https://providers.ucsd.edu/det....ails/11935/orthopedi
UC San Diego Health is repeatedly ranked among the nation's best in orthopedic care by U.S. News & World Report. We are also a Blue Distinction Center recognized for our treatment expertise and better overall patient results for knee replacement, as well as a designated Center of Excellence for orthopedic care by Optum. This means you'll receive expert, safe and cost-effective care.
UC San Diego Health's orthopedic surgeons are the first and only in San Diego to offer customized knee replacements with the ROSA knee system — for a faster recovery and more natural feeling knee. Talk to one of our surgeons about whether a ROSA knee replacement is right for you. https://health.ucsd.edu/specia....lties/orthopedics/jo#a
When taking oral corticosteroids longer term, you may experience: Clouding of the lens in one or both eyes (cataracts) High blood sugar, which can trigger or worsen diabetes. Increased risk of infections. Thinning bones (osteoporosis) and fractures. Suppressed adrenal gland hormone production
The vast majority of glucocorticoid activity in most mammals is from cortisol, also known as hydrocortisone. Corticosterone, the major glucocorticoid in rodents, is another glucocorticoid. Cortisol binds to the glucocorticoid receptor in the cytoplasm and the hormone-receptor complex is then translocated into the nucleus, where it binds to its DNA response element and modulates transcription from a battery of genes, leading to changes in the cell's phenotype. Only about 10% of circulating cortisol is free. The remaining majority circulates bound to plasma proteins, particularly corticosteroid-binding globulin (transcortin). This protein binding likely decreases the metabolic clearance rate of glucocorticoids and, because the bound steroid is not biologically active, tends to act as a buffer and blunt wild fluctuations in cortisol concentration.
Dumping syndrome is a condition that can develop after surgery to remove all or part of your stomach or after surgery to bypass your stomach to help you lose weight. Also called rapid gastric emptying, dumping syndrome occurs when food, especially sugar, moves from your stomach into your small bowel too quickly. Most people with dumping syndrome develop signs and symptoms, such as abdominal cramps and diarrhea, 10 to 30 minutes after eating. Other people have symptoms one to three hours after eating, and still others have both early and late symptoms. Generally, you can help prevent dumping syndrome by changing your diet after surgery. Changes might include eating smaller meals and limiting high-sugar foods. In more-serious cases o
CPAP, or continuous positive airway pressure, is a treatment that uses mild air pressure to keep the airways open. CPAP typically is used by people who have breathing problems, such as sleep apnea. CPAP also may be used to treat preterm infants whose lungs have not fully developed.
In this video, learn how to suture like a plastic surgeon! We'll go over the different types of sutures, appropriate needle sizes, and the correct technique for suturing different types of wounds. Whether you're a medical student or just interested in improving your suturing skills, this video is for you! Join us and start mastering this essential surgical skill.
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The superior sagittal sinus (also known as the superior longitudinal sinus), within the human head, is an unpaired area along the attached margin of falx cerebri. It allows blood to drain from the lateral aspects of anterior cerebral hemispheres to the confluence of sinuses.
-Korsakoff's syndrome is a common and preventable sequel of Wernicke's encephalopathy. Thiamine, if given during the stage of Wernicke's encephalopathy, can prevent the onset of Korsakoff's psychosis. The administration of glucose prior to thiamine can precipitate Korsakoff's syndrome, as seen in this case. In such patients, brain MRI frequently shows abnormal enhancement of the mammillary bodies & thallamus
The patient has spasticity in the lower extremities greater than the upper extremities. The hips and knees are flexed and adducted with the ankles extended and internally rotated. When the patient walks both lower extremities are circumducted and the upper extremities are held in a mid or low guard position. This type of gait is usually seen with bilateral periventricular lesions. The legs are more affected than the arms because the corticospinal tract axons that are going to the legs are closest to the ventricles.
Gastric bypass, also called Roux-en-Y gastric bypass surgery, is considered a “metabolic” procedure because it changes how your body absorbs fat, calories and nutrients. This metabolic change occurs because your gastrointestinal tract is altered when your gastric bypass surgeon attaches the smaller section of your stomach directly to your small intestine. As a result, your appetite changes and you feel full faster.