A new report analyzing FDA-approved monoclonal antibodies (mAbs) produced by a select group of leading biotechnology companies shows that clinical development times – specifically the duration of Phase II and Phase III trials – are lengthening, while FDA review times have remained constant. The average time from investigational new drug (IND) filing to market was 6.7 years for 11 mABs approved between 1994 and 2003 but shot up to 8.3 years for 12 mAbs approved between 2004 and March 9, 2011, according to Deloitte Recap LLC’s analysis, Therapeutic Monoclonal Antibodies – Insights, Strategies and Data.

Endoscopic retrograde cholangiopancreatography, or ERCP, is a specialized technique used to study the bile ducts, pancreatic duct and gallbladder. Ducts are drainage routes; the drainage channels from the liver are called bile or biliary ducts. The pancreatic duct is the drainage channel from the pancreas.

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Obstetrics is the field of medicine which encompasses the care of a woman during pregnancy and childbirth. In that way it is very unique, as when assessing these patients, your actually also assessing another the child.

A narrowing of the major artery (the aorta) that carries blood to the body. This narrowing affects blood flow where the arteries branch out to carry blood along separate vessels to the upper and lower parts of the body. CoA can cause high blood pressure or heart damage.

Ehlers-Danlos syndrome is a group of disorders that affect the connective tissues that support the skin, bones, blood vessels, and many other organs and tissues. Defects in connective tissues cause the signs and symptoms of Ehlers-Danlos syndrome, which vary from mildly loose joints to life-threatening complications. Previously, there were more than 10 recognized types of Ehlers-Danlos syndrome, differentiated by Roman numerals. In 1997, researchers proposed a simpler classification that reduced the number of major types to six and gave them descriptive names: the classical type (formerly types I and II), the hypermobility type (formerly type III), the vascular type (formerly type IV), the kyphoscoliosis type (formerly type VIA), the arthrochalasia type (formerly types VIIA and VIIB), and the dermatosparaxis type (formerly type VIIC). This six-type classification, known as the Villefranche nomenclature, is still commonly used. The types are distinguished by their signs and symptoms, their underlying genetic causes, and their patterns of inheritance. Since 1997, several additional forms of the condition have been described. These additional forms appear to be rare, affecting a small number of families, and most have not been well characterized.

A doctor explains the purpose of dialysis and explains the difference between hemodialysis and peritoneal dialysis. Learn more at https://www.niddk.nih.gov/heal....th-information/kidne

The menstrual cycle is the regular natural change that occurs in the female reproductive system like the uterus and ovaries that make pregnancy possible. The cycle is required for the production of ovocytes, and for the preparation of the uterus for pregnancy.

Adrenoleukodystrophy, or ALD, is a deadly genetic disease that affects 1 in 18 000 people. It most severely affects boys and men. This brain disorder destroys myelin, the protective sheath that surrounds the brain's neurons -- the nerve cells that allow us to think and to control our muscles.

Nelson syndrome refers to a spectrum of symptoms and signs arising from an adrenocorticotropin (ACTH)–secreting pituitary macroadenoma after a therapeutic bilateral adrenalectomy. The spectrum of clinical features observed relates to the local effects of the tumor on surrounding structures, the secondary loss of other pituitary hormones, and the effects of the high serum concentrations of ACTH on the skin. [1] The first case was reported by Nelson et al in 1958. [2]

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A blood transfusion is a routine medical procedure that can be lifesaving. During a blood transfusion, donated blood is added to your own blood. A blood transfusion may also be done to supplement various components of your blood with donated blood products. In some cases, a blood transfusion is done with blood that you've donated ahead of time before you undergo elective surgery. During a typical blood transfusion, certain parts of blood are delivered through an intravenous (IV) line that's placed in one of the veins in your arm. A blood transfusion usually takes one to four hours, though in an emergency it can be done much faster.

She is a twenty years young female presented with large cystic swelling in anterior aspect of neck. The swelling was of size 6cmx 6cm x5 cm ,tense tender, cystic just above sternal nutch.This was diagnosed as large neck abscess ./nRepeated aspiration done but the swelling reappeared. So Incision & Drainage planned under local anaesthesia./nPatient in supine position. Surgery part painted and draped. Local anaesthesia 2% xylocaine with adrenaline used for field block.After giving local anaesthesia, I used a no 11 blade for stab incision at the most prominent part of the swelling, where skin was thin and fluctuation present./nPus drained form that opening. Little dilatation of opening to be done with artery forceps or sinus forceps. Complete pus drainage to be ensured.Little finger can be introduced inside the pus cavity to ensure proper drainage of pus. The cavity I use to clean with a gauge piece. If necessary curette biopsy can be taken from the wall of the cavity.These wounds usually need daily proper dressing for faster healing.

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Several options are available to remove spider veins — thin red lines or weblike networks of blood vessels that appear on your legs and feet. Spider veins are usually harmless, though they can sometimes cause aching, burning or pain, especially when you've been standing for long periods. If you have symptoms or are concerned about the appearance of spider veins, treatment options include: Sclerotherapy. In this procedure, your doctor injects the veins with a solution that scars and closes those veins, causing the blood to reroute through healthier veins. In a few weeks, treated spider veins fade. Although the same vein may need to be injected more than once, sclerotherapy is usually effective if done correctly. Sclerotherapy doesn't require anesthesia and can be done in your doctor's office. Side effects include swelling, itching and skin color changes in the treated area. Laser surgery. Laser surgery works by sending strong bursts of light into the vein that make the vein slowly fade and disappear. No incisions or needles are used. The treatment is often less effective than sclerotherapy, particularly for larger veins. Side effects may include redness, bruising, itching, swelling and permanent skin tone changes. After treatment, blood vessels fade over several months, but they may not disappear completely. Also, new spider veins can develop in the same area.

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Case of ITP with persistent very low platelet count despite best medical management

a sleeve gastrectomy with very few edditing. During the start 3 smal spleen perforations caused by Veres Needle were identified, caused by a giant spleen undentified on pre operatory ultrasound. They were controled with gauze compression and at the end of the surgery surgicel was placed and no complications were observed. Patient discharged 3 days after the surgery.

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Antibiotic therapy is the mainstay of medical treatment for pediatric rhinosinusitis.] Because of increasing prevalence of beta-lactam–resistant bacteria in the community, administer antibiotics only for suspected infection as based on a careful history and physical examination. Direct the therapeutic regimen against the prevalent pathogens in the community and carefully consider suspicion for highly resistant bacteria. Typically, uncomplicated cases of acute sinusitis are responsive to amoxicillin. Most patients respond to this initial regimen. For children allergic to penicillin, a second- or third-generation cephalosporin can be used (only if the allergic reaction is not a type 1 hypersensitivity reaction). In cases of serious allergic reaction, a macrolide or clindamycin can be used.