Small cell lung cancer, which occurs almost exclusively in smokers, is a malignancy characterised by rapid doubling time, high growth fraction and widespread metastasis at presentation. In this presentation, we will briefly discuss the classification of pulmonary Neuro-endocrine tumours by the World Health Organisation followed by a detailed discussion of the clinical features, lab evaluation and management of SCLC, both limited and extended stage. The frontline therapy in small cell lung cancer is etoposide and cisplatin along with thoracic radiotherapy and prophylactic cranial irradiation in patients who have a good response to therapy. Hyperfractionation of radiotherapy may provide some benefit but is also associated with increase incidence of complications. Newer agents for SCLC include Vandetanib and immunotherapy molecules, such as Iplimumab and nivolumab.

Mr Brian MacCormack talking about Paediatric Surgery Emergencies. This talk is part of the Paediatric Emergencies 2022 event. To get your CME certificate for watching the video please visit https://www.paediatricemergenc....ies.com/conference/p

#PaediatricEmergencies #PaediatricEmergencies2022 #PaediatricSurgery

At Nationwide Children’s, our Department of General Pediatric Surgery provides comprehensive surgical care for infants, children and adolescents with congenital and acquired conditions, including major congenital anomalies, traumatic and thermal injuries, and tumors. As the second largest pediatric treatment center in the United States our surgeons perform more than 4,000 operative procedures every year. We are dedicated to clinical excellence, generation of new knowledge through research and the training of the next generation of leaders in children’s surgery. Under the umbrella of a unified program, 11 surgical departments share a common mission, philosophy and approach to patient care.

Pediatric Surgery Program: https://bit.ly/3t4QZef
Pediatric Surgery Fellowship and Residency: https://bit.ly/3qWAWwd
Meet our Pediatric Surgery Team: https://bit.ly/3n39dJh
Fellowship Programs: https://bit.ly/3EX1JNX
Surgical Services: https://bit.ly/3eYDlB8

PARAPHARYNGEAL SPACE TUMORS: SURGICAL APPROACH

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First described by Aubaniac in 1952, central venous catheterization, or central line placement, is a time-honored and tested technique of quickly accessing the major venous system. Benefits over peripheral access include greater longevity without infection, line security in situ, avoidance of phlebitis, larger lumens, multiple lumens for rapid administration of combinations of drugs, a route for nutritional support, fluid administration, and central venous pressure (CVP) monitoring. Central vein catheterization is also referred to as central line placement. Overall complication rates are as high as 15%, [1, 2, 3, 4] with mechanical complications reported in 5-19% of patients, [5, 6, 7] infectious complications in 5-26%, [1, 2, 4] and thrombotic complications in 2-26%. [1, 8] These complications are all potentially life-threatening and invariably consume significant resources to treat. Placement of a central vein catheter is a common procedure, and house staff require substantial training and supervision to become facile with this technique. A physician should have a thorough foreknowledge of the procedure and its complications before placing a central vein catheter. The supraclavicular approach was first put into clinical practice in 1965 and is an underused method for gaining central access. It offers several advantages over the infraclavicular approach to the subclavian vein. At the insertion site, the subclavian vein is closer to the skin, and the right-side approach offers a straighter path into the subclavian vein. In addition, this site is often more accessible during cardiopulmonary resuscitation (CPR) and during active surgical cases. Finally, in patients who are obese, this anatomic area is less distorted.

A pacemaker insertion is the implantation of a small electronic device that is usually placed in the chest (just below the collarbone) to help regulate slow electrical problems with the heart.

People with celiac disease may lose weight because their bodies are not able to absorb enough nutrients from food. Over time, a range of problems may develop as a result of the body's reaction to gluten — from skin rashes and lactose intolerance to infertility, bone weakness and nerve damage.

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Though most snakes aren't venomous, the ones with a deadly bite are so scary that many researchers think humans evolved to naturally fear the sinuous creatures. With good reason. In the video, two men milk the venom of a Russell's viper and then show what happens when one drop of that venom mixes with a glassful of human blood. It's terrifying.

During your menstrual period, your uterus contracts to help expel its lining. Hormonelike substances (prostaglandins) involved in pain and inflammation trigger the uterine muscle contractions. Higher levels of prostaglandins are associated with more-severe menstrual cramps.

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An omentectomy is a surgical procedure designed to remove the omentum, which is a thin fold of abdominal tissue that encases the stomach, large intestine and other abdominal organs. This fatty lining contains lymph nodes, lymph vessels, nerves and blood vessels.

The only way to completely avoid anal sex risks is to abstain from anal sex. If you engage in anal sex, it is always important to use a condom to protect against the spread of infections and diseases.

Nonalcoholic fatty liver disease is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. As the name implies, the main characteristic of nonalcoholic fatty liver disease is too much fat stored in liver cells. Nonalcoholic steatohepatitis, a potentially serious form of the disease, is marked by liver inflammation, which may progress to scarring and irreversible damage. This damage is similar to the damage caused by heavy alcohol use. At its most severe, nonalcoholic steatohepatitis can progress to cirrhosis and liver failure Nonalcoholic fatty liver disease is increasingly common around the world, especially in Western nations. In the United States, it is the most common form of chronic liver disease, affecting an estimated 80 to 100 million people. Nonalcoholic fatty liver disease occurs in every age group but especially in people in their 40s and 50s who are at high risk of heart disease because of such risk factors as obesity and type 2 diabetes. The condition is also closely linked to metabolic syndrome, which is a cluster of abnormalities including increased abdominal fat, poor ability to use the hormone insulin, high blood pressure and high blood levels of triglycerides, a type of fat. Nonalcoholic fatty liver disease care at Mayo Clinic Request an Appointment at Mayo Clinic Symptoms & causes Aug. 23, 2016 Print Share on: Facebook Twitter References Related Magnetic resonance elastography Nonalcoholic fatty liver disease Overview Symptoms & causes Diagnosis & treatment Diagnosis Treatment Departments & specialties Expertise & rankings Locations, travel & lodging Clinical trials Research Costs & insurance Preparing for your appointment Self-management More about In-Depth Multimedia Resources News from Mayo Clinic Advertisement

A spider nevus is a collection of small, dilated arterioles (blood vessels) clustered very close to the surface of the skin. The cluster of vessels is web-like, with a central spot and radiating vessels.

For this surgery, your doctor makes a large incision in the abdomen to expose the aorta. Once he or she has opened the abdomen, a graft can be used to repair the aneurysm. Open repair remains the standard procedure for an abdominal aortic aneurysm repair. Endovascular aneurysm repair (EVAR).

Inner Workings tells the story of the ceaseless pull of the human heart — even as it works against the very stoic realism of the brain.