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Mohammed Wahba
8,190 Views ยท 1 year ago

Details about the nature and procedure for this "something" will be in the next video ..soon.

Scott Stevens
16,916 Views ยท 1 year ago

Cisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tumors. The molecule was first discovered in 1845, but did not receive FDA approval until 1978. Today it is known as the "penicillin of cancer drugs," because it is so effective for many different cancers. There are three key players involved in Cisplatin's mechanism: (1) Cisplatin, (2) DNA (3) and an HMG Protein. Most Cisplatin enters the body through active transport, but some molecules are passively defused through the cell membrane. Once in the nucleus, Cisplatin can form an adduct with two consecutive guanine bases within a strand of DNA. The molecule loses its chlorine atoms in exchange for the nitrogen atoms of the target guanines. Cisplatin can bond more tightly with nitrogen because nitrogen balances the platinum charge more effectively than chlorine. It is this adduct-induced DNA bend that allows binding of proteins which contain the high mobility group, HMG domain. Once the protein is bound to the DNA, it inserts a wedge-like phenyl group of phenylalanine 37 into the widened minor groove created by the bend. The tightly bound HMG protein causes destacking of the nucleotide bases, resulting in the DNA helix becoming kinked. In this way, Cisplatin can be thought of as a monkey wrench in the DNA repair system. With the HMG protein bound to the DNA, the modified strand is not repaired properly and so the cell dies. The success of Cisplatin depends on its ratio of efficacy between cancerous and healthy cells.

Scott Stevens
1,178 Views ยท 1 year ago

Coronary Artery Bypass Surgery CABG Heart

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Laparoscopy in Hemodynamic Instable Patient

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Histology of Medium Artery and Vein

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10,097 Views ยท 1 year ago

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dr. kamal hussein saleh al husseiny
1,212 Views ยท 1 year ago

AL EMADI HOSPITAL-QATAR-DOHA AMERICAN BOARD CERTIFICATE AESTHETIC MEDICINE 0097455742973 drkhsh2001@yahoo.com http://www.kamalsaleh.sptechs.com

dr. kamal hussein saleh al husseiny
1,128 Views ยท 1 year ago

AL EMADI HOSPITAL-QATAR-DOHA AMERICAN BOARD CERTIFICATE AESTHETIC MEDICINE 0097455742973

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9,309 Views ยท 1 year ago

Carotid Endarterectomy Surgery

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Scientifically Erectile Dysfunction Penile Implants

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7,305 Views ยท 1 year ago

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6,378 Views ยท 1 year ago

Pelvic lymphadenectomy




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