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Queen Anne's sign
System: Hormone & Metabolic Signs · All hormone & metabolic signs
What it is — and how it is elicited
Thinning or loss of the outer third of the eyebrows.
What a positive finding suggests
Traditionally associated with an underactive thyroid (hypothyroidism).
◈ Behind the name
Traditionally named after Anne of Denmark (1574–1619), queen consort of James I, in whose portraits the feature was said to be visible.
Related signs — Hormone & Metabolic Signs
Browse the Q section of the A–Z list or return to the Clinical Signs hub.
Please note: This page is an educational reference about clinical examination signs. A clinical sign supports — and never replaces — a full clinical evaluation, examination and appropriate testing. A sign being present does not by itself prove a diagnosis, and an absent sign does not rule one out. If you have symptoms that worry you, see a health professional.