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Piperacillin-tazobactam
Pronounced pye-PER-ah-sil-in tay-zo-BAK-tam
Brand names: Zosyn
Type: Penicillin antibiotic with beta-lactamase inhibitor · All Antibiotics & Infection Medicines
What Piperacillin-tazobactam is used for
- Serious hospital infections of the lungs, abdomen, and skin
- Infections in people with low white blood cell counts
- Diabetic foot infections
◆ Kidney note
Dose is lowered when kidney function is reduced; often combined with vancomycin, which together raises kidney strain — kidney tests are followed closely.
Common side effects
- Diarrhea
- Nausea
- Headache
- Trouble sleeping
Important cautions
- True penicillin allergy can be life-threatening — always tell your care team about any past reaction
- Used in hospital, often combined with other antibiotics with monitoring of kidneys and blood counts
How it comes
Injection (hospital). This guide lists forms only — it never lists strengths or doses.
Toxicity lists: Piperacillin-tazobactam also appears on Medicines That Can Harm the Kidneys.
Related medicines — Antibiotics & Infection Medicines
Please note: This page is a patient-education summary, not medical advice, and it deliberately contains no doses. Medicines affect everyone differently — always follow your own prescription and talk to your doctor or pharmacist before starting, stopping or changing any medicine.