Benzodiazepines
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Benzodiazepines are a class of agents that work on the central nervous system, acting selectively on gamma-aminobutyric acid-A (GABA-A) receptors in the brain. GABA is a neurotransmitter that inhibits or reduces the activity of nerve cells (neurons) within the brain. Benzodiazepines open GABA-activated chloride channels, and allow chloride ions to enter the neuron. This makes the neuron negatively charged and resistant to excitation.
This video in 30 seconds
This video explains benzodiazepines, a class of agents that work on the central nervous system, acting selectively on GABA-A receptors in the brain. It covers GABA as a neurotransmitter that inhibits nerve cell activity, and how benzodiazepines open GABA-activated chloride channels, allowing chloride ions to enter the neuron and making it negatively charged and resistant to excitation.
Key points
- Defines benzodiazepines as agents acting on the central nervous system
- Covers selective action on GABA-A receptors in the brain
- Explains GABA as an inhibitory neurotransmitter
- Explains chloride channel opening and the neuron becoming resistant to excitation as described
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