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Denosumab
Pronounced den-OH-syoo-mab
Brand names: Prolia, Xgeva
Type: RANKL inhibitor (bone medicine injection) · All Hormone & Endocrine Medicines
What Denosumab is used for
- Osteoporosis in women and men
- Bone loss from hormone treatment for prostate or breast cancer
- Bone complications of cancer
◆ Kidney note
Not cleared by the kidneys, so no dose change is needed — but low calcium risk is highest in severe kidney disease and dialysis, so calcium is monitored closely.
Common side effects
- Back pain
- Muscle or joint pain
- Skin rash or eczema
- High cholesterol readings
Important cautions
- Can lower blood calcium, sometimes severely — calcium and vitamin D are corrected before treatment
- Stopping or delaying it after long use can quickly raise spine fracture risk — keep appointments on schedule
How it comes
Injection under the skin (clinic). This guide lists forms only — it never lists strengths or doses.
Related medicines — Hormone & Endocrine Medicines
Please note: This page is a patient-education summary, not medical advice, and it deliberately contains no doses. Medicines affect everyone differently — always follow your own prescription and talk to your doctor or pharmacist before starting, stopping or changing any medicine.