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Sulfasalazine
Pronounced sul-fah-SAL-ah-zeen
Brand names: Azulfidine
Type: Aminosalicylate and disease-modifying medicine · All Digestive (GI) Medicines
What Sulfasalazine is used for
- Ulcerative colitis
- Crohn disease
- Rheumatoid arthritis
◆ Kidney note
Use with caution and good hydration in kidney impairment, as crystals in urine are a rare problem.
Common side effects
- Nausea
- Headache
- Loss of appetite
- Orange-yellow urine and skin tint
- Rash
Important cautions
- Sulfa allergy must be reported before use
- Can lower blood counts and sperm counts (reversible) — monitoring blood tests are part of treatment
- Extra folic acid is often recommended because it reduces folate absorption
How it comes
Tablets, delayed-release tablets, liquid. This guide lists forms only — it never lists strengths or doses.
Toxicity lists: Sulfasalazine also appears on Medicines That Can Harm the Kidneys and Medicines That Can Harm the Liver.
Related medicines — Digestive (GI) Medicines
Please note: This page is a patient-education summary, not medical advice, and it deliberately contains no doses. Medicines affect everyone differently — always follow your own prescription and talk to your doctor or pharmacist before starting, stopping or changing any medicine.