E22.1 — Hyperprolactinemia
E22.1

What this code means
Hyperprolactinaemia is a raised level of the hormone prolactin, which can affect periods, fertility and milk production.
Also called: hyperprolactinemia, high prolactin.
When this code is used
Used for hyperprolactinaemia.
Where it sits in ICD-10-CM
Code E22.1 belongs to Chapter 4: Endocrine, nutritional and metabolic diseases, which covers codes E00–E89 in the FY2027 ICD-10-CM tabular list. The official description above is copied verbatim from the CDC/NCHS FY2027 code file.
Frequently asked questions
What is ICD-10-CM code E22.1?
E22.1 is the ICD-10-CM diagnosis code for “Hyperprolactinemia”. Hyperprolactinaemia is a raised level of the hormone prolactin, which can affect periods, fertility and milk production.
When is code E22.1 used?
Used for hyperprolactinaemia. It belongs to Chapter 4 of ICD-10-CM (Endocrine, nutritional and metabolic diseases).
This guide explains ICD-10-CM codes in plain language for patients, students and other readers. It is educational information only — not coding, billing or medical advice. The code recorded for any real encounter is assigned from the full clinical documentation by the treating team and qualified coders, and only they can decide which code fits a specific case.