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Sirolimus
Pronounced sir-OH-li-mus
Brand names: Rapamune
Type: mTOR inhibitor immunosuppressant · All Transplant & Immune Medicines
What Sirolimus is used for
- Preventing organ rejection after kidney transplant
- A rare lung disease (lymphangioleiomyomatosis)
- Coating heart stents (in the device, not taken as a pill)
◆ Kidney note
Does not directly poison the kidney the way calcineurin inhibitors can, but it increases protein in the urine in some patients, so kidney tests and urine protein are followed.
Common side effects
- Mouth sores
- Raised cholesterol and triglycerides
- Swelling of legs
- Diarrhea
- Acne
- Delayed wound healing
Important cautions
- Blood levels are monitored, and it impairs wound healing — surgical teams plan around it before operations
- Raises infection risk and can cause lung inflammation in rare cases
How it comes
Tablets, liquid. This guide lists forms only — it never lists strengths or doses.
Toxicity lists: Sirolimus also appears on Medicines That Can Harm the Kidneys.
Related medicines — Transplant & Immune Medicines
Condition guides on MedicalVideos.com
Please note: This page is a patient-education summary, not medical advice, and it deliberately contains no doses. Medicines affect everyone differently — always follow your own prescription and talk to your doctor or pharmacist before starting, stopping or changing any medicine.