Systemic lupus erythematosus!
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Systemic lupus erythematous is an autoimmune condition characterised by damage to organ systems due to autoantibodies and immune complex deposition. Genes, epigenetic changes and environment play a role in its pathogenesis. SLE is a truly multi system disease causing widespread clinical manifestations in almost all organ systems. Autoantibodies in SLE are numerous and mainly include ANA, dsDNA, Sm and others.
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This presentation covers systemic lupus erythematosus. It describes SLE as an autoimmune condition characterised by damage to organ systems due to autoantibodies and immune complex deposition, with genes, epigenetic changes and environment playing a role in its pathogenesis, as a truly multisystem disease with manifestations in almost all organ systems, and lists autoantibodies including ANA, dsDNA and Sm among others.
Key points
- SLE is described as an autoimmune condition with organ damage from autoantibodies and immune complex deposition
- Genes, epigenetic changes and environment are described as playing a role in pathogenesis
- Multisystem manifestations in almost all organ systems are described
- Autoantibodies listed include ANA, dsDNA and Sm
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