Coagulation and thrombophilia tests

Category: Biopsies, Lab & Pathology Tests · All biopsies, lab & pathology tests

Coagulation and thrombophilia tests — Biopsies, Lab & Pathology Tests

What it is

Coagulation tests measure how blood clots: routine tests (PT/INR, APTT) guide warfarin treatment and pre-operative assessment; platelet function and von Willebrand tests investigate bleeding; thrombophilia tests look for inherited or acquired clotting tendencies after blood clots.

Why it is done

They are used to monitor anticoagulants, investigate unusual bruising/bleeding or clotting, assess before surgery, and explore causes of miscarriage in selected situations and of clots at young ages or unusual sites.

How to prepare

Timing matters: some tests are invalid while taking anticoagulants or during an acute clot or pregnancy — your haematology team will schedule them correctly. Provide a full medicine list and family history of bleeding or clotting.

What happens during the procedure

Sampling is a standard blood draw into citrate tubes that must be filled exactly to the line (the blood-to-anticoagulant ratio matters). Some specialised tests need the sample processed quickly, which the laboratory arranges.

Afterwards — recovery & results

Results range from same-day (INR) to weeks (thrombophilia panels). They are interpreted by haematology with your history, because many results are borderline or affected by circumstances — a 'positive' thrombophilia result does not always change management.

Risks & considerations

No physical risks beyond the draw. The main caution is over-testing: thrombophilia screening is deliberately selective, as results can cause anxiety without improving outcomes for many people.

Frequently asked questions

Why test my INR so often on warfarin?

Warfarin levels shift with diet, illness and other medicines. Regular INR keeps you in the range where clots are prevented without excessive bleeding risk.

Should everyone with a clot get thrombophilia testing?

No — testing is targeted where results would change decisions (for example very young patients, strong family history, or clots in unusual places). Your haematologist advises case by case.

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Please note: This page is educational information about a medical procedure or test. It does not replace the instructions of your own care team, who know your situation and whose preparation, fasting and medication advice you should follow if it differs from anything here. If you have symptoms that worry you, or an appointment you do not understand, contact your clinical team.