The pathobiology of MM is complex and the root underlying cause of myeloma is the multistep genetic changes in the postgerminal center B cell. In addition, the bone marrow microenvironment plays a crucial role.[2] The interaction between myeloma cells and the microenvironment is mediated through adhesive interactions via cell-surface receptors, paracrine loops involving several cytokines, such as IL-6, VEGF and IL-10, and suppression of cell-mediated immunity.[2–4] IMiDs modulate many of these interactions leading to decreased myeloma cell growth and survival. Thalidomide was the first IMiD introduced to treat MM. It was initially synthesized in Germany in the late 1950s to treat insomnia and morning sickness. It was withdrawn from the market in 1961 because of its teratogenic effects. Its immunomodulatory properties were realized when it was observed to improve erythema nodosum leprosum, a painful immunologic reaction of leprosy, leading to its approval by the FDA in 1998 with tight prescribing and marketing regulations. Subsequent research showed the diverse mechanism of action of thalidomide including its immunomodulatory effect by inhibition of de novo IgM antibody synthesis,[5] modulation of the T-cell subset by increasing the T-helper cells, inhibitory effects on the TNF-α and antiangiogenic activity leading to its use in MM. Significantly higher response rates in combination with dexamethasone led to its approval in the treatment of newly diagnosed MM in 2006. Lenalidomide, a second-generation IMiD, was developed from the structural backbone of the thalidomide molecule by the addition of an amino group (NH2-) at position 4 of the phthaloyl ring and removal of the carbonyl group (C = O) of the 4-amino-substituted phthaloyl ring (Table 1).[6] In addition to immunomodulatory effects, other mechanisms of action have been described such as direct cytotoxicity via induction of apoptosis, inhibition of cell adhesion molecules and inhibition of growth signals that promote bone marrow angiogenesis

When the hematocrit rises to 60 or 70%, which it often does in polycythemia, the blood viscosity can become as great as 10 times that of water, and its flow through blood vessels is greatly retarded because of increased resistance to flow. This will lead to decreased oxygen delivery.

There are four major blood groups determined by the presence or absence of two antigens – A and B – on the surface of red blood cells: Group A – has only the A antigen on red cells (and B antibody in the plasma) Group B – has only the B antigen on red cells (and A antibody in the plasma) Group AB – has both A and B antigens on red cells (but neither A nor B antibody in the plasma) Group O – has neither A nor B antigens on red cells (but both A and B antibody are in the plasma)

Disc Disease Videos Watch Disc Disease Videos There are several symptoms that are fairly consistent for people with lower back pain or neck pain from degenerative disc disease, including: Pain that is usually related to activity and will flare up at times but then return to a low-grade pain level, or the pain will go away entirely The amount of chronic pain—referred to as the patient's baseline level of pain—is quite variable between individuals and can range from almost no pain/just a nagging level of irritation, to severe and disabling pain Severe episodes of back or neck pain that will generally last from a few days to a few months before returning to the individual's baseline level of chronic pain Chronic pain that is completely disabling from degenerative disc disease does happen in some cases, but is relatively rare See Treating Chronic Pain and Depression from Degenerative Disc Disease

Triplet C-section

This video is a teaching aid for use in conjunction with broader surgical training

Treatment of periodontal disease - Scaling and root planing

Gross Tooth extraction ( For root removal )

Removal of multiple teeth due to advanced periodontal disease.

Many people report that inversion table therapy is a great way to stretch muscles and ligaments, reduce muscle spasms, and improve circulation. Stretching stimulates the lymph glands to increase the flow of lymphatic fluids; part of the body's waste disposal system. Similarly, cellular health depends on good blood circulation to deliver nourishment and remove waste. Inversion table therapy also helps to relieve motion sickness and stress. In addition, the body becomes more aware of its spatial orientation and balance when the inner ear is stimulated during inversion. Plus, it is not necessary for the body to be positioned completely upside down to gain benefits from inversion therapy! Unlike antigravity boots used with an inversion rack, an adjustable inversion table offers the flexibility to choose the most comfortable angle. Dialogue with Your Doctor Like anything that can affect your health, talk to your doctor before you start using an inversion table. This is important because certain medications and health conditions may make using an inversion table unsafe. Your doctor may recommend against inversion table therapy if you have obesity, a detached retina, fracture, glaucoma, heart condition (circulatory problem), hernia, implanted device, middle ear or eye infection, osteoporosis, are pregnant, or have a spinal injury. There may be other medical conditions not listed that your doctor may view as a contraindication.

American spinal decompression therapy ociation home leading specialists in find certified doctor your area how to do back traction at out about the best options when you want decompress spine for fast pain relief and devices non surgical is revolutionary new technology used primarily treat disc injuries neck low this treatment option chiropractic center denton. Chiropractor dr vince baugher uses variety of adjusting methods make sure adjustments feel great produce results intellibed experience with our advanced bed mattress system performing alert nal nothing more sought after than ways perform intent health can help relieve excessive pressure on disks between verte here are exercises oakspine gentle sciatica using proven it right.

Decompression is a surgical procedure that is performed to alleviate pain caused by pinched nerves (neural impingement). During a lumbar decompression back surgery, a small portion of the bone over the nerve root and/or disc material from under the nerve root is removed to give the nerve root more space and provide a better healing environment. There are two common types of spine surgery decompression procedures: Microdiscectomy Lumbar Microdiscectomy Microdiscectomy Surgery Video A microdiscectomy (a microdecompression) is typically performed for pain from a lumbar herniated disc. The surgery is considered reliable for leg pain caused by the herniated disc, most commonly called sciatica by patients, and most commonly referred to by medical practitioners as a radiculopathy. Read more about Microdiscectomy Surgery

Gastroschisis is a birth defect of the abdominal (belly) wall. The baby’s intestines stick outside of the baby’s body, through a hole beside the belly button. The hole can be small or large and sometimes other organs, such as the stomach and liver, can also stick outside of the baby’s body. Gastroschisis occurs early during pregnancy when the muscles that make up the baby’s abdominal wall do not form correctly. A hole occurs which allows the intestines and other organs to extend outside of the body, usually to the right side of belly button. Because the intestines are not covered in a protective sac and are exposed to the amniotic fluid, the bowel can become irritated, causing it to shorten, twist, or swell.

A voice prosthesis (plural prostheses) is an artificial device, usually made of silicone that is used to help laryngectomized patients to speak. During a total laryngectomy, the entire voice box (larynx) is removed and the windpipe (trachea) and food pipe (esophagus) are separated from each other.

Rare condition disorder known as Diprosopus, also known as craniofacial duplication. Diprosopus is a congenital defect also known as craniofacial duplication. The exact description of diprosopus refers to a fetus with a single trunk, normal limbs, and facial features that are duplicated to a certain degree. A less severe instance is when the fetus has a duplicated nose and the eyes are spaced far apart. In the most extreme instances, the entire face is duplicated, hence the name diprosopus, which is Greek for two-faced. Fetuses with diprosopus often also lack brains (anencephaly), have neural tube defects, or heart malformations. In some cases, if the brain is formed, it may have duplicated structures. Most infants with diprosopus are stillborn and there are fewer than fifty cases documented since 1864.

The human heart explained in 1 minute Video by Dr. Mo

According to a Danish study , frequent sex may help prevent pre-eclampsia. Researchers believe it's because of a protein found in sperm that can regulate the body's immune system. Yet because the cause of preeclampsia is unknown, it's important to keep your prenatal visits and talk to your doctor about your risk.

If you're pregnant or might become pregnant, it's critically important to get enough folic acid, the synthetic form of vitamin B9, also known as folate. Folic acid helps prevent neural tube defects (NTDs) – serious birth defects of the spinal cord (such as spina bifida) and the brain (such as anencephaly).

Is Air Travel During Pregnancy Safe? Traveling by air is considered safe for women while they are pregnant; however, the following ideas might make your trip safer and more comfortable. Most airlines allow pregnant women to travel through their eighth month.

Airline travel. When you're pregnant, the safest time to travel is during your second trimester (18 to 24 weeks), when your risks for miscarriage and preterm labor are lowest. During your third trimester, it's best to stay within 300 miles of home, in case of sudden changes that need medical attention.