Immune System

Immune System anatomy
Immune System — anatomical illustration
Video still from MedicalVideos.com: the immune system

The immune system is the distributed defence network of white blood cells, antibodies and the organs that house them — bone marrow, thymus, spleen, lymph nodes, tonsils and the lymphoid tissue of the gut and airways. It distinguishes self from non-self, fights infection, removes damaged cells and keeps watch for cancers, using a fast innate arm (barriers, phagocytes, inflammation) and a precise adaptive arm (T and B lymphocytes) that remembers past invaders — the basis of vaccination.

Key facts

  • Neutrophils, the commonest white cells, live only days; some memory lymphocytes persist for a lifetime.
  • Antibodies (immunoglobulins) are made by plasma cells derived from B lymphocytes — up to thousands of molecules per second per cell.
  • About 70% of immune tissue is associated with the gut, sampling the body's largest surface of contact with the outside world.
  • Fever is a deliberate immune strategy: higher temperature inhibits many microbes and speeds white cell activity.

What can go wrong

Immune problems divide into too little (immunodeficiency — from HIV, medicines, or inherited defects — causing recurrent or unusual infections), too much misdirected (allergy and autoimmune diseases such as rheumatoid arthritis and type 1 diabetes, where the system attacks the body's own tissues), and malignant change in its cells (leukaemia and lymphoma).

Related conditions

Related procedures & tests

Related symptoms

Watch: related videos

Frequently asked questions

How do vaccines train the immune system?

They present a harmless form of a microbe (or its blueprint) so the adaptive system builds memory cells; on real exposure, the response is fast and strong enough to prevent or blunt illness.

What is an autoimmune disease?

A condition where immune tolerance fails and lymphocytes or antibodies attack the body's own tissues — the target tissue determines the disease, from joints to thyroid to nerve insulation.

Educational information only. This atlas explains normal anatomy and describes conditions in general terms; it is not medical advice and does not replace assessment by a qualified clinician. If you have symptoms that worry you, seek medical care.

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