Faecal calprotectin and stool tests

Category: Digestive Tests & Procedures · All digestive tests & procedures

Faecal calprotectin and stool tests — Digestive Tests & Procedures

What it is

Stool tests analyse a small sample of faeces in the laboratory. Key examples are faecal calprotectin, which reflects inflammation in the bowel, the FIT test, which detects hidden blood, and tests for infections such as C. difficile and parasites.

Why it is done

Calprotectin helps distinguish inflammatory bowel disease from irritable bowel syndrome and monitors known inflammation. FIT is used to investigate bowel symptoms and in bowel screening programmes. Infection tests are used for diarrhoea that is persistent, bloody or follows travel or antibiotics.

How to prepare

There is usually no preparation; some tests ask you to avoid certain medicines or foods only if the laboratory instructs. You will be given a kit with a scoop and instructions to collect the sample without contaminating it with urine or toilet water.

What happens during the procedure

There is no procedure to attend for most stool tests — you collect the sample at home, seal and label the pot, and return it promptly as instructed. Blood and other tests can be arranged at the same time if your doctor wants a fuller picture.

Afterwards — recovery & results

Results usually take a few days to a week depending on the test. Your doctor will explain what the level means — for example a raised calprotectin usually leads to further bowel investigation, while a normal result makes active inflammation less likely.

Risks & considerations

These tests are risk-free to perform. Their limitation is accuracy: a single sample can miss intermittent problems, and some medicines (such as anti-inflammatory painkillers) can affect inflammation markers, so results are interpreted in context.

Frequently asked questions

What is a normal calprotectin?

Laboratories set their own ranges, but low values generally make active bowel inflammation unlikely, while clearly high values suggest inflammation that needs investigation. Your result letter or doctor will interpret yours.

Why was my FIT positive but colonoscopy normal?

FIT detects blood from anywhere in the bowel, including piles and minor causes, and some positives have no serious explanation. A normal colonoscopy afterwards is reassuring.

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Please note: This page is educational information about a medical procedure or test. It does not replace the instructions of your own care team, who know your situation and whose preparation, fasting and medication advice you should follow if it differs from anything here. If you have symptoms that worry you, or an appointment you do not understand, contact your clinical team.